Cognitive disturbances in the cuprizone model of multiple sclerosis

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چکیده

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“The cuprizone model and multiple sclerosis: disparities and similarities“

Diese Dissertation ist auf den Internetseiten der Hochschulbibliothek online verfügbar.

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Background: Bone marrow mesenchymal stem cells (BM-MSCs) elicit neuroprotective effects, and their repair ability has been investigated in different experimental models. We aimed to investigate the effect of multiple i.p. BM-MSCs injections in the cuprizone model of multiple sclerosis in mice. Methods: Adult male C57BL/6 mice (n = 40) were fed a regular diet or a diet containing cuprizone (0.2%...

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The Effect of Aerobic Training with the Consumption of Probiotic on the Myelination of Nerve Fibers in Cuprizone-Induced Demyelination Mouse Model of Multiple Sclerosis

Introduction: Extensive human and animal research shows that exercise has beneficial effects on multiple clinical outcomes for patients suffering from multiple sclerosis (MS). This research was an attempt to address the effect of aerobic training with the consumption of probiotic on the myelination of nerve fibers in a cuprizone-induced demyelination mouse model of MS. Methods: Mice, which we...

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Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis

Previous studies on the degenerative animal model of multiple sclerosis suggested that the copper-chelator cuprizone might directly suppress T-cell functions. Peripheral T-cell function in the cuprizone model has already been explored; therefore, in the present study, we investigated, for the first time, how cuprizone feeding affects the thymus, the organ of T-cell maturation and selection. We ...

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promotion of remyelination by adipose mesenchymal stem cell transplantation in a cuprizone model of multiple sclerosis

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ژورنال

عنوان ژورنال: Genes, Brain and Behavior

سال: 2020

ISSN: 1601-1848,1601-183X

DOI: 10.1111/gbb.12663